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Implications for practice and research
■ In children presenting with vomiting from acute gastroenteritis, ondansetron is a reasonable therapy to allow for successful oral rehydration.
■ Further research on ondansetron and rehydration should investigate the effects of different dosing regimens, time to cessation of vomiting after antiemetic administration, as well as a cost-effectiveness analysis.
Acute gastroenteritis (AGE) is a common reason for a child to require emergency care and hospitalisation. In children under the age of 5 years, dehydration secondary to AGE is responsible for as many as 200 000 hospitalisations in the USA and 24 000 in the UK each year.1 2
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