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Implications for practice and research
▪ The study findings that daily aspirin reduced cancer death by 20% need to be factored into guideline recommendations. The large effect size of aspirin, even in low dose, in preventing cancer may outweigh the small risk of stomach bleeds.
▪ It may be recommended that persons at age 40 take daily low-dose aspirin to prevent cancer, not just of adenocarinoma of the gastrointestinal tract but of adenocarinoma of other tumour sites.
▪ More trial data are needed on cancers that affect women, especially breast and gynaecological cancers.
Cancer is a major cause of mortality and morbidity; yet methods of prevention for many cancers remain unknown. Studies in animal models show aspirin reduces cancer incidence; however, observational studies in humans report equivocal …
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