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Systematic review with meta analysis
Taking aspirin daily for at least 4 years reduces long-term risk of cancer death
  1. Elizabeth Ann Coleman
  1. College of Nursing, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
  1. Correspondence to Elizabeth Ann Coleman
    Mail Slot 529, 4301 West Markham Street, Little Rock, AR 72205, USA; colemanann{at}uams.edu

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Implications for practice and research

  • The study findings that daily aspirin reduced cancer death by 20% need to be factored into guideline recommendations. The large effect size of aspirin, even in low dose, in preventing cancer may outweigh the small risk of stomach bleeds.

  • It may be recommended that persons at age 40 take daily low-dose aspirin to prevent cancer, not just of adenocarinoma of the gastrointestinal tract but of adenocarinoma of other tumour sites.

  • More trial data are needed on cancers that affect women, especially breast and gynaecological cancers.

Context

Cancer is a major cause of mortality and morbidity; yet methods of prevention for many cancers remain unknown. Studies in animal models show aspirin reduces cancer incidence; however, observational studies in humans report equivocal …

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