Administration of annual oral high-dose vitamin D to community dwelling older women in autumn and winter months increases risk of falls and fractures
- University of Tampa, Tampa, Florida, USA
- Correspondence to Cathy R Kessenich
401 W. Kennedy Blvd, Tampa, FL 33606, USA;
- Published Online First 30 July 2010
Vitamin D deficiency is an increasingly important worldwide issue. It is estimated that one billion people worldwide have vitamin D deficiency or insufficiency.1 Vitamin D deficiency has been linked to a multitude of problems across the lifespan. The importance of vitamin D and calcium absorption has been well documented. What remains unclear is the role of vitamin D in osteoporotic fracture prevention and specifically, the amount and regimen of vitamin D ingestion that is safe and effective in decreasing falls and subsequent fractures.
Sanders and colleagues conducted the largest randomised clinical trial to date of the effects of giving a year's supply of vitamin D in a single dose. The study hypothesis …