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Randomised controlled trial
Prophylactic paracetamol at the time of infant vaccination reduces the risk of fever, but also reduces antibody response
  1. S Songül Yalçin
  1. Correspondence to S Songül Yalçin
    Faculty of Medicine, Department of Pediatrics, Hacettepe University, Samanpazari, Ankara, Turkey

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Childhood immunisations are often associated with local and systemic adverse reactions. Although usually benign, mild and self-limited, adverse events following childhood immunisation can result in discomfort in the child and family, and the adverse reaction to a previous vaccination is one of the main reasons for non-immunisation of children.1 The Advisory Committee on Immunization Practices and the American Academy of Pediatrics recommend prophylactic use of antipyretics in infants and children at high risk for seizures. A previous review2 showed that the use of prophylactic paracetamol and ibuprofen may reduce the incidence of adverse reactions only in infants aged 2–6 months receiving the DTPw …

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