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Q Does a dietary modification intervention promoting a low fat dietary pattern reduce risk of breast cancer, colorectal cancer, or cardiovascular disease (CVD) in postmenopausal women?
METHODS
Design:
3 reports of different outcome measures of a randomised controlled trial (Women’s Health Initiative [WHI]).
Allocation:
{concealed}.*
Blinding:
blinded (physician adjudicators verifying outcomes, {data collectors, data analysts, and monitoring committee}*).
Follow up period:
mean 8.1 years.
Setting:
40 clinical centres in the US.
Participants:
48 835 postmenopausal women 50–79 years of age (mean age 62 y) with baseline fat intake ⩾32% of total calories. Exclusion criteria were previous cancer (except for non-melanoma skin cancer) in the past 10 years, medical conditions with predicted survival <3 years, type 1 diabetes, adherence concerns such as alcoholism or dementia, or frequent consumption of meals prepared away from home.
Intervention:
low fat dietary pattern intervention (n = 19 541) or no dietary intervention (n = 29 294). The dietary modification intervention promoted dietary change with the goals of reducing …
Footnotes
↵* Information provided by authors.
For correspondence: Dr R L Prentice, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. rprentice{at}whi.org Dr S A Beresford, University of Washington, Seattle, WA, USA. beresfrd{at}u.washington.edu Dr B V Howard, MedStar Research Institute, Hyattsville, MD, USA. Barbara.v.howard{at}medstar.net
Source of funding: National Heart, Lung, and Blood Institute.