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  • A low fat dietary pattern intervention did not reduce breast cancer, colorectal cancer, or CVD in postmenopausal women

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A low fat dietary pattern intervention did not reduce breast cancer, colorectal cancer, or CVD in postmenopausal women

https://doi.org/10.1136/ebn.9.4.112

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    Prentice RL, Caan B, Chlebowski RT, et al. Low-fat dietary pattern and risk of invasive breast cancer: the Women’s Health Initiative Randomized Controlled Dietary Modification Trial. JAMA 2006;295:629–42.OpenUrlCrossRefPubMedWeb of ScienceBeresford SA, Johnson KC, Ritenbaugh C, et al. Low-fat dietary pattern and risk of colorectal cancer: the Women’s Health Initiative Randomized Controlled Dietary Modification Trial. JAMA 2006;295:643–54.OpenUrlCrossRefPubMedWeb of ScienceHoward BV, Van Horn L, Hsia J, et al. Low-fat dietary pattern and risk of cardiovascular disease: the Women’s Health Initiative Randomized Controlled Dietary Modification Trial JAMA 2006;295:655–66.OpenUrlCrossRefPubMedWeb of Science

    Q Does a dietary modification intervention promoting a low fat dietary pattern reduce risk of breast cancer, colorectal cancer, or cardiovascular disease (CVD) in postmenopausal women?

    METHODS

    Embedded ImageDesign:

    3 reports of different outcome measures of a randomised controlled trial (Women’s Health Initiative [WHI]).

    Embedded ImageAllocation:

    {concealed}.*

    Embedded ImageBlinding:

    blinded (physician adjudicators verifying outcomes, {data collectors, data analysts, and monitoring committee}*).

    Embedded ImageFollow up period:

    mean 8.1 years.

    Embedded ImageSetting:

    40 clinical centres in the US.

    Embedded ImageParticipants:

    48 835 postmenopausal women 50–79 years of age (mean age 62 y) with baseline fat intake ⩾32% of total calories. Exclusion criteria were previous cancer (except for non-melanoma skin cancer) in the past 10 years, medical conditions with predicted survival <3 years, type 1 diabetes, adherence concerns such as alcoholism or dementia, or frequent consumption of meals prepared away from home.

    Embedded ImageIntervention:

    low fat dietary pattern intervention (n = 19 541) or no dietary intervention (n = 29 294). The dietary modification intervention promoted dietary change with the goals of reducing …

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    Footnotes

    • ↵* Information provided by authors.

    • For correspondence: Dr R L Prentice, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. rprentice{at}whi.org Dr S A Beresford, University of Washington, Seattle, WA, USA. beresfrd{at}u.washington.edu Dr B V Howard, MedStar Research Institute, Hyattsville, MD, USA. Barbara.v.howard{at}medstar.net

    • Source of funding: National Heart, Lung, and Blood Institute.