Evid Based Nurs 9:107 doi:10.1136/ebn.9.4.107
  • Treatment

Review: vaccines prevent influenza and influenza-like illness in healthy children <16 years of age

 Q In healthy children <16 years of age, are influenza vaccines efficacious (ie, prevent confirmed influenza) and effective (ie, prevent influenza-like illness)?


GraphicData sources:

Medline (1966–2004), EMBASE/Excerpta Medica (1974–2004), Cochrane Library (Issue 1, 2005), Biological Abstracts (1969–2004), Science Citation Index (1974–2004), Vaccine Adverse Event Reporting System website (, vaccine manufacturers, and authors of relevant studies.

GraphicStudy selection and assessment:

randomised controlled trials (RCTs), semi-randomised, cohort, and case-control studies in any language that enrolled healthy children <16 years of age in any geographical location; compared any influenza vaccine (including unlicensed types) given independently, in any dose, preparation, or time schedule, with placebo or no intervention. 51 studies (n = 263 987) met the selection criteria: 14 RCTs and …

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