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Review: vaccines prevent influenza and influenza-like illness in healthy children <16 years of age

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Q In healthy children <16 years of age, are influenza vaccines efficacious (ie, prevent confirmed influenza) and effective (ie, prevent influenza-like illness)?

METHODS

Embedded ImageData sources:

Medline (1966–2004), EMBASE/Excerpta Medica (1974–2004), Cochrane Library (Issue 1, 2005), Biological Abstracts (1969–2004), Science Citation Index (1974–2004), Vaccine Adverse Event Reporting System website (http://www.vaers.org), vaccine manufacturers, and authors of relevant studies.

Embedded ImageStudy selection and assessment:

randomised controlled trials (RCTs), semi-randomised, cohort, and case-control studies in any language that enrolled healthy children <16 years of age in any geographical location; compared any influenza vaccine (including unlicensed types) …

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Footnotes

  • For correspondence: Dr S Smith, Oxford University, Oxford, UK.

  • Source of funding: no funding.