Evid Based Nurs 9:86 doi:10.1136/ebn.9.3.86
  • Treatment

Adding topical pale sulfonated shale oil to compression therapy and moist wound care reduced venous leg ulcer size but had no effect on complete wound healing after 20 weeks

 Q Does topical application of pale sulfonated shale oil (PSSO) in addition to usual care with compression therapy and standard moist wound care improve healing of venous leg ulcers?



randomised controlled trial.




blinded {patients, healthcare providers, data collectors, and outcome assessors}.*

GraphicFollow up period:

to the end of the 20 week treatment period.


13 outpatient wound clinics in Germany and Slovakia.


119 patients >18 years of age (mean age 69 y, 67% women) who had leg ulcers ⩾3 cm2 caused by chronic venous insufficiency. Exclusion criteria were severe cardiac, respiratory, gastrointestinal, liver, or renal disease; malignancy; signs of wound infection; and pregnancy or lactation.


10% Leukichtan PSSO gel (Ichthyol-Gesellschaft, Germany) (n = 62) or placebo gel (n = 57). Both gels were applied daily as a 2–2.5 mm thick layer directly onto the wound surface and covered by a non-adherent gauze dressing (Jelonet, Smith & Nephew Medical, Germany). Compression therapy was applied …

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