Evid Based Nurs 9:84 doi:10.1136/ebn.9.3.84
  • Treatment

Oestrogen and progestin increased urge and stress incontinence in postmenopausal women with coronary heart disease

 Q In postmenopausal women with coronary heart disease, does oestrogen and progestin treatment affect the risk of stress and urge urinary incontinence (UI)?



secondary analysis of a randomised placebo controlled trial (Heart Estrogen/progestin Replacement Study [HERS]).




blinded {patients, investigators, and outcome assessors}.*

GraphicFollow up period:

4–48 months.


20 clinical centres in the US.


1228 postmenopausal women <80 years of age who had coronary heart disease, an intact uterus, and reported no episodes of UI within the past week. {Exclusion criteria included use of oral, parenteral, vaginal, or transdermal hormones within 3 months; intolerance to hormone therapy; fasting blood sugar concentration ⩾300 mg/dl; serum triglyceride concentration ⩾300 mg/dl; serum glutamic oxaloacetic transaminase >1.2 times normal; history of …

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