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Review: routine changes of IV administration sets (not containing lipids or blood products) at intervals ⩽96 hours do not affect infusate or catheter related bloodstream infection

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 Q What is the optimal interval for routine replacement of IV administration sets when infusate or parenteral nutrition solutions are administered by central or peripheral venous catheters?

METHODS

Embedded ImageData sources:

Cochrane Central Register of Controlled Trials, Medline, CINAHL, and EMBASE/Excerpta Medica (all up to February 2004); reference lists; and researchers.

Embedded ImageStudy selection and assessment:

randomised or quasi-randomised controlled trials that assessed the effects of different frequencies of replacing IV administration sets among inpatients of any age receiving parenteral nutrition (lipid and non-lipid containing solutions) or infusions (excluding blood) by central or peripheral catheter. 13 studies (n = 4783) met the selection criteria. Methodological quality of individual studies was assessed based on allocation concealment and loss to follow up.

Embedded ImageOutcomes:

infusate colonisation, infusate related bloodstream infection (BSI), catheter colonisation, catheter related BSI, all cause BSI, and mortality. …

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