Evid Based Nurs 9:81 doi:10.1136/ebn.9.3.81
  • Treatment

Review: routine changes of IV administration sets (not containing lipids or blood products) at intervals ⩽96 hours do not affect infusate or catheter related bloodstream infection

 Q What is the optimal interval for routine replacement of IV administration sets when infusate or parenteral nutrition solutions are administered by central or peripheral venous catheters?


GraphicData sources:

Cochrane Central Register of Controlled Trials, Medline, CINAHL, and EMBASE/Excerpta Medica (all up to February 2004); reference lists; and researchers.

GraphicStudy selection and assessment:

randomised or quasi-randomised controlled trials that assessed the effects of different frequencies of replacing IV administration sets among inpatients of any age receiving parenteral nutrition (lipid and non-lipid containing solutions) or infusions (excluding blood) by central or peripheral catheter. 13 studies (n = 4783) met the selection criteria. Methodological quality of individual studies was assessed based on allocation concealment and loss to follow up.


infusate colonisation, infusate related bloodstream infection (BSI), catheter colonisation, catheter related BSI, all cause BSI, and mortality. …

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