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Review: lorazepam provides the best control for status epilepticus

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 Q In patients with status epilepticus (SE), which anticonvulsant drugs are most effective?

METHODS

Embedded ImageData sources:

Cochrane Epilepsy Group Specialised Register, Cochrane Central Database of Controlled Trials, Medline, EMBASE/Excerpta Medica, and bibliographies of relevant studies.

Embedded ImageStudy selection and assessment:

randomised or quasi-randomised controlled trials (RCTs) that compared any anticonvulsant drug with placebo or another anticonvulsant drug in patients with premonitory, early stage, established, or refractory SE. Quality assessment of individual studies was based on randomisation method, baseline comparability of groups, blinding, and intention to treat analysis. 11 RCTs (n = 2017) met the selection criteria. Patients had premonitory (5 RCTs), established (1 RCT), refractory (1 RCT), and mixed SE (2 RCTs); 2 RCTs did not …

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