Review: aspirin was effective for primary prevention of stroke in women and MI in men but increased major bleeding
Q What are the benefits and risks of aspirin for primary prevention of cardiovascular (CV) disease in women and men?
Medline (1966 to March 2005), bibliographies of retrieved articles, and monitoring of major scientific meetings.
Study selection and assessment:
randomised controlled trials (RCTs) that allocated participants to aspirin or a control group for primary prevention of CV disease and outcomes included CV mortality, myocardial infarction (MI), and stroke. Quality of individual studies was assessed based on allocation concealment, follow up, and objectivity of outcome assessments. 6 RCTs (51 342 women and 44 114 men, mean age 55–65 y) met the selection criteria. Aspirin dosage ranged from 100 mg every other day to 500 mg daily. Patient follow up was >95% in all trials, and duration of …