Evid Based Nurs 9:52 doi:10.1136/ebn.9.2.52
  • Treatment

Supplemental perioperative oxygen at 80% FIO2 reduced surgical site infections in elective colorectal surgery

 Q In patients having elective colorectal resection, does supplemental perioperative oxygen reduce the risk of surgical site infection (SSI)?



randomised controlled trial (RCT).




blinded (patients, surgical team, data collectors, outcome assessors, and monitoring committee).

GraphicFollow up period:

14 days after surgery.


14 hospitals in Spain.


300 patients 18–80 years of age who were having elective colorectal resection. Exclusion criteria were minor colon surgery (eg, polypectomy or isolated colostomy) or laparoscopic surgery, expected duration of surgery <1 hour, fever or existing signs of infection, diabetes mellitus, HIV infection, >20% weight loss in past 3 months, serum albumin concentration <30 g/l, or leucocyte count <2500 cells/ml.


during surgery, patients were administered an oxygen/air mixture with a fraction of inspired oxygen (FIO2) of 80% (n = 150) or 30% (n = 150). After surgery was completed, the inhaled anaesthetic was stopped, and FIO2 was …

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