Supplemental perioperative oxygen at 80% FIO2 reduced surgical site infections in elective colorectal surgery
Q In patients having elective colorectal resection, does supplemental perioperative oxygen reduce the risk of surgical site infection (SSI)?
METHODS
Design:
randomised controlled trial (RCT).
Allocation:
concealed.
Blinding:
blinded (patients, surgical team, data collectors, outcome assessors, and monitoring committee).
Follow up period:
14 days after surgery.
Setting:
14 hospitals in Spain.
Patients:
300 patients 18–80 years of age who were having elective colorectal resection. Exclusion criteria were minor colon surgery (eg, polypectomy or isolated colostomy) or laparoscopic surgery, expected duration of surgery <1 hour, fever or existing signs of infection, diabetes mellitus, HIV infection, >20% weight loss in past 3 months, serum albumin concentration <30 g/l, or leucocyte count <2500 cells/ml.
Intervention:
during surgery, patients were administered an oxygen/air mixture with a fraction of inspired oxygen (FIO2) of 80% (n = 150) or 30% (n = 150). After surgery was completed, the inhaled anaesthetic was stopped, and FIO2 was …
