Evid Based Nurs 9:51 doi:10.1136/ebn.9.2.51
  • Treatment

Review: once daily LMWH is as effective as twice daily LMWH for initial treatment of venous thromboembolism

 Q Is once daily low molecular weight heparin (LMWH) as effective (for reducing recurrent venous thromboembolism [VTE]) and as safe (with respect to major haemorrhagic events) as twice daily LMWH in the initial treatment of VTE?


GraphicData sources:

Cochrane Peripheral Vascular Diseases Specialized Trials Register (up to April 2005), Cochrane Central Register of Controlled Trials (CENTRAL) (Cochrane Library, Issue 1, 2005), Medline (up to April 2005), EMBASE/Excerpta Medica (up to April 2005), and bibliographies of relevant articles.

GraphicStudy selection and assessment:

randomised controlled trials (RCTs) in any language that compared (in an intention to treat analysis) once daily with twice daily use of a fixed dose of subcutaneous LMWH as initial treatment in patients with objectively documented VTE (deep venous thromboembolism [DVT] or pulmonary embolism [PE]). Study quality was assessed using the Jadad scale. Trials without adequate …

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