Review: antibiotic prophylaxis reduces mortality in patients with neutropenia
Q Does antibiotic prophylaxis, particularly fluoroquinolone prophylaxis, reduce mortality in patients with neutropenia?
Medline (1966–2004), EMBASE/Excerpta Medica (1980–2004), Cochrane Cancer Network register of trials (December 2004), Cochrane Library (Issue 4, 2004), and references of included studies and reviews.
Study selection and assessment:
published and unpublished randomised controlled trials (RCTs) in any language that compared antibiotic therapy with placebo, no intervention, or other antibiotics for prophylaxis of bacterial infection in patients with neutropenia. Individual study quality was assessed based on allocation concealment, generation of allocation sequence, blinding, and intention to treat analysis.
primary outcome was all cause mortality; secondary outcomes included infection related mortality, fungal infection, adverse events, and risk of harbouring drug resistant bacilli.
95 RCTs (n = 9283, mostly adults) met the selection criteria. 64 trials included …