Evid Based Nurs 9:49 doi:10.1136/ebn.9.2.49
  • Treatment

Inhaled insulin added to or replacing 2 oral agents reduced haemoglobin A1c concentrations in type 2 diabetes

 Q Does inhaled insulin added to or replacing 2 oral agents reduce haemoglobin A1c (HbA1c) concentrations in type 2 diabetes?



randomised controlled trial.





GraphicFollow up period:

12 weeks.


48 outpatient centres in the US and Canada.


309 outpatients 35–80 years of age (mean age 57 y, 65% men) who were diagnosed with type 2 diabetes ⩾1 year earlier, were treated with a stable oral agent regimen of 2 antidiabetic medications (1 insulin secretagogue and 1 insulin sensitiser), and had HbA1c concentrations of 8–11%. Exclusion criteria were predisposition to severe hypoglycaemia; hospital admission or emergency department visit for poor diabetic control in the past 6 months; body mass index >35 kg/m2; clinically significant respiratory disease or major organ system disease; …

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