Evid Based Nurs 9:45 doi:10.1136/ebn.9.2.45
  • Treatment

Paracetamol, non-steroidal anti-inflammatory drugs, and combination treatment did not differ for pain relief after musculoskeletal injury

 Q What is the relative effectiveness of oral paracetamol (acetaminophen), oral non-steroidal anti-inflammatory drugs (NSAIDs), and combination treatment for acute pain relief after musculoskeletal injury?



randomised placebo controlled trial.


unclear concealment.


blinded (patients, healthcare providers, and outcome assessors).

GraphicFollow up period:

5–8 days after initial presentation. Pain was assessed up to 3 days.


emergency department (ED) of a university teaching hospital in Hong Kong.


300 patients ⩾16 years of age (mean age 37 y, 59% men) who presented to the ED with a painful acute limb injury. Exclusion criteria were substance abuse; dementia; indigestion; peptic ulceration or haemorrhage; recent anticoagulation; pregnancy; adverse reactions to study drugs; renal or cardiac failure; hepatic problems; rectal bleeding; chronic NSAID consumption; asthma; chronic obstructive airways disease; chronic pain syndromes; previous analgesia for the same injury; or physical, visual, or cognitive impairment.


oral …

No Related Web Pages

Free Sample

This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of EBN.
View free sample issue >>

EBN Journal Chat

The EBN Journal Chat offers readers the opportunity to participate in discussion about research articles and commentaries from Evidence Based Nursing (EBN).

How to participate >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

Navigate This Article