Review: antibiotics are more effective than placebo for acute bacterial rhinosinusitis
Q What are the relative efficacies of various antibiotics for treatment of acute bacterial rhinosinusitis? Does duration of treatment affect efficacy?
Medline (1997 to September 2004), reference lists of relevant reviews, and technical experts.
Study selection and assessment:
published English language randomised controlled trials (RCTs) that included ⩾10 patients per group and compared antibiotics with placebo or other antibiotics in patients of any age with acute (<30 d) uncomplicated bacterial sinusitis or acute exacerbation of chronic sinusitis. Studies of patients with chronic sinusitis only or other respiratory infections were excluded. 2 reviewers independently assessed studies for methodological quality using a 3 category score based on level of bias.
treatment failure (lack of improvement or worsening of signs and symptoms by the end of treatment) and recurrence (persistent or relapsed disease ⩾1 wk after the end of treatment).
39 RCTs (15 739 patients) met the …