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Review: antibiotics are more effective than placebo for acute bacterial rhinosinusitis

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 Q What are the relative efficacies of various antibiotics for treatment of acute bacterial rhinosinusitis? Does duration of treatment affect efficacy?

METHODS

Embedded ImageData sources:

Medline (1997 to September 2004), reference lists of relevant reviews, and technical experts.

Embedded ImageStudy selection and assessment:

published English language randomised controlled trials (RCTs) that included ⩾10 patients per group and compared antibiotics with placebo or other antibiotics in patients of any age with acute (<30 d) uncomplicated bacterial sinusitis or acute exacerbation of chronic sinusitis. Studies of patients with chronic sinusitis only or other respiratory infections were excluded. 2 reviewers independently assessed studies for methodological quality using a 3 category score based on level of bias.

Embedded ImageOutcomes:

treatment failure (lack of improvement or worsening of signs and symptoms by the end of treatment) and recurrence (persistent or relapsed disease ⩾1 wk after the end of treatment).

MAIN RESULTS

39 RCTs (15 739 patients) met the …

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