The WHO technique for intramuscular thigh vaccination in infants and toddlers had fewer adverse reactions than 2 other techniques
Q In infants and toddlers, which of 3 techniques for giving intramuscular thigh vaccinations results in the fewest adverse reactions?
METHODS
Design:
randomised controlled trial.
Allocation:
{concealed}.*
Blinding:
blinded {participants and data collectors}.*
Follow up period:
24 hours.
Setting:
a general practice in Taree, New South Wales, Australia.
Participants:
375 consecutive healthy children who were 2, 4, 6, or 18 months of age.
Intervention:
intramuscular injection into the anterolateral thigh of diphtheria-tetanus-acellular pertussis-hepatitis B vaccine (InfanrixHepB, GlaxoSmithKline) for children 2, 4, and 6 months of age or diphtheria-tetanus-acellular pertussis vaccine (Infanrix, GlaxoSmithKline) for children 18 months of age, using 1 of 3 techniques: Australian (23 gauge, 25 mm long needle inserted at the junction of the upper and middle thirds of the vastus lateralis at 45–60° to the skin, pointing …
