Evid Based Nurs 9:22 doi:10.1136/ebn.9.1.22
  • Treatment

An educational booklet did not improve adherence or symptoms in patients prescribed thyroxine for primary hypothyroidism

 Q Does an educational booklet addressing lay health beliefs about medicine-taking improve adherence in patients prescribed thyroxine for primary hypothyroidism?



randomised controlled trial.


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blinded (laboratory staff assessing thyroid stimulating hormone [TSH] assays).

GraphicFollow up period:

median 96 days.


3 suburban general practices (18 physicians) in northwest England, UK.


332 patients ⩾18 years of age (mean age 62 y, 92% women) who were taking a stable dose of thyroxine (ie, dose unchanged over the previous 8 wks) for primary hypothyroidism caused by thyroidectomy, radio-iodine treatment, or autoimmune thyroiditis. Patients with serious illness were excluded.


166 patients were allocated to receive an educational booklet by post a few days after the initial assessment; …

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