Article Text

PDF

Topical chloramphenicol was not effective for acute infective conjunctivitis in children

Statistics from Altmetric.com


 
 Q In children with acute infective conjunctivitis, is topical chloramphenicol effective for inducing clinical cure?

METHODS

Embedded ImageDesign:

randomised controlled trial.

Embedded ImageAllocation:

concealed.

Embedded ImageBlinding:

blinded (patients, healthcare providers, data collectors, outcome assessors, and data analysts).

Embedded ImageFollow up period:

7 days for the primary outcome plus an extra 5 weeks to assess relapse.

Embedded ImageSetting:

12 primary practices in Oxfordshire, UK.

Embedded ImagePatients:

326 children 6 months to 12 years of age (mean age 3 y, 53% boys) who had acute infective conjunctivitis. Exclusion criteria included allergy to chloramphenicol, use of antibiotics (current or within the previous 48 h), evidence of severe infection, and children who were immunocompromised.

Embedded ImageIntervention:

0.5% chloramphenicol (preservation-free eye drops BP)(n = 163) or placebo (distilled water with the excipients boric acid, 1.5%, and borax, 0.3%)(n = 163). Parents were …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.