Evid Based Nurs 9:10 doi:10.1136/ebn.9.1.10
  • Treatment

Liposomal lidocaine improved intravenous cannulation success rates in children

 Q In children, does use of liposomal lidocaine before intravenous (IV) cannulation improve cannulation success rates and reduce pain, procedure duration, and adverse skin reactions more than placebo?



randomised placebo controlled trial.




blinded (patients and healthcare providers).

GraphicFollow up period:

immediately after first cannulation attempt.


emergency department of a children’s hospital in Toronto, Ontario, Canada.


151 children who were 1 month to 17 years of age and required a peripheral IV cannula. Exclusion criteria were critical illness requiring immediate cannulation (eg, sepsis or severe dehydration), known or suspected hypersensitivity to local anaesthetics, current administration of opioid or topical anaesthesia, or previous participation.


4% liposomal lidocaine cream, 1 g, (n = 76) or placebo (n = 75). The nurse selected 2 possible sites for cannulation and applied lidocaine or placebo cream for 30 minutes under occlusion with Tegaderm or IV …

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