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Protein energy supplementation of usual hospital diet did not improve outcomes in inpatients with recent stroke
  1. Cami D’Uva, RN, MN, ACNP,
  2. Charmaine Martin, RN, MSc(T), ACNP
  1. Integrated Stroke Unit, Hamilton Health Sciences
 Hamilton, Ontario, Canada

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 Q Does routine oral protein energy supplementation of a usual hospital diet improve outcomes in patients admitted with recent stroke?

    METHODS

    Embedded ImageDesign:

    randomised controlled trial (FOOD [Feed Or Ordinary Diet] trials).

    Embedded ImageAllocation:

    concealed.

    Embedded ImageBlinding:

    blinded (outcome assessors).

    Embedded ImageFollow up period:

    median 6.7 months.

    Embedded ImageSetting:

    125 hospitals in 15 countries.

    Embedded ImagePatients:

    4023 patients (mean age 71 y, 53% men, 8% undernourished) who were admitted with a recent stroke (first or recurrent stroke ⩽7 d before admission) and whose clinicians were uncertain about whether to use oral nutritional supplements after they had passed the swallow screen. Patients with subarachnoid haemorrhage were excluded. Patients could be enrolled within the first 30 days of admission or within 30 days of stroke occurring in hospital.

    Embedded ImageIntervention:

    usual hospital diet plus oral protein energy supplements (equivalent to 360 ml at 6.27 kJ/ml and 62.5 g/l in protein every day) (n = 2016) or usual hospital diet alone (n = 2007) until discharge.

    Embedded ImageOutcomes:

    a composite end point of all cause mortality or poor outcome (defined as modified Rankin scale [MRS] scores 3–5; 0  =  no symptoms to 5  =  requiring constant attention); and all cause mortality.

    Embedded ImagePatient follow up:

    99.7% (intention to treat analysis).

    MAIN RESULTS

    The groups did not differ for rates of the composite outcome or all cause mortality (table).

    CONCLUSION

    Routine oral protein energy supplementation of a usual hospital diet did not improve outcomes in patients admitted with recent stroke.

    Commentary

    Nutritional status at stroke onset is a prognostic factor for stroke outcome.1 The relation between feeding and stroke outcomes were investigated by Dennis et al. The trial showed that routine oral protein energy supplementation did not lead to better outcomes in all stroke patients. However, the results did suggest a potential benefit for patients who were undernourished at hospital admission.

    Study strengths included use of centralised randomisation, high follow up rates, and data collection systems that enabled the recruitment of a large number of patients.

    The FOOD trial is clinically important because it highlights the issue of nutrition and its relation to health outcomes. Further research is needed to investigate the benefits of oral supplementation in malnourished patients at stroke onset.

    Nurses have a vital role in early recognition and management of complications associated with feeding difficulties and malnutrition.2 Malnutrition is a commonly occurring, yet often unrecognised problem in patients with stroke.3 Although it makes intuitive sense to routinely add nutritional supplements to the diet of all patients with stroke, the FOOD trial did not support this practice. This observation reinforces the need for nurses to incorporate a series of standardised nutritional screens into the admission assessments and ongoing reassessments of all patients with stroke.4 The use of such nutritional screens in the context of a patient centred approach to care will guide nurses in their use of nutritional supplements in patients with stroke.

    Usual hospital diet plus oral protein energy supplements v usual hospital diet alone in patients admitted with recent stroke*

    
 
 Q Does routine oral protein energy supplementation of a usual hospital diet improve outcomes in patients admitted with recent stroke?

    View Abstract

    Footnotes

    • A modified version of this abstract appears in ACP Journal Club.

    • For correspondence: Professor M Dennis, Western General Hospital, Edinburgh, UK. martin.dennised.ac.uk

    • Sources of funding: National Health Service Research and Development, UK; Stroke Association; Chief Scientist Office of the Scottish Executive; Chest, Heart and Stroke, Scotland; and Royal Australasian College of Physicians.

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    References