|Drug class||Drug||Number of RCTs||Level of evidence and recommendation|
|Osmotic laxatives||Polyethylene glycol||8 (5 placebo controlled)||Good evidence supports use; better than lactulose|
|Lactulose||11 (3 placebo controlled)||Moderate evidence supports use|
|Bulking agents||Psyllium||9 (3 placebo controlled)||Moderate evidence supports use|
|Calcium polycarbophil||1 (v psyllium)||Poor evidence for or against use|
|Bran||4 (1 placebo controlled)||Poor evidence for or against use|
|Methylcellulose||1 (v psyllium)||Poor evidence for or against use|
|Softening or wetting agents||Dioctyl (docusate) calcium, dioctyl sodium||4 (1 placebo controlled)||Poor evidence for or against use; psyllium better|
|Stimulant laxatives||Senna||1 v sodium picosulfate; 1 v bran||Poor evidence for or against use|
|Bisacodyl||1 v bisoxatin||Poor evidence for or against use|
|Other agents||Tegaserod||1 placebo controlled||Good evidence supports use|
Review: good evidence supports use of polyethylene glycol and tegaserod for constipation
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