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Evid Based Nurs 8:109 doi:10.1136/ebn.8.4.109
  • Treatment

Review: good evidence supports use of polyethylene glycol and tegaserod for constipation


 
 Q How effective and safe are various medical therapies in patients with chronic constipation?

METHODS

GraphicData sources:

Medline (1966–2004) and bibliographies of relevant studies and reviews.

GraphicStudy selection and assessment:

randomised controlled trials (RCTs) that compared medical therapies with placebo or compared 2 separate agents in adults with constipation. Assessment of study quality was done using a 5 point score (5  =  highest quality) based on randomisation procedure, allocation concealment, blinding, and completeness of follow up.

GraphicOutcomes:

stool frequency, stool consistency, straining, use of additional laxatives, ease of defecation, and side effects.

MAIN RESULTS

Laxatives evaluated were osmotic laxatives (eg, polyethylene glycol [PEG], lactulose, milk of magnesia, and sorbitol), irritant and stimulant laxatives (eg, senna and bisacodyl), bulking agents (eg, psyllium [ispaghula], methylcellulose, …

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