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Treatment
Review: good evidence supports use of polyethylene glycol and tegaserod for constipation

https://doi.org/10.1136/ebn.8.4.109

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    Ramkumar D, Rao SS. Efficacy and safety of traditional medical therapies for chronic constipation: systematic review. Am J Gastroenterol 2005;100:936–71.OpenUrlCrossRefPubMedWeb of Science

    Q How effective and safe are various medical therapies in patients with chronic constipation?

    METHODS

    Embedded ImageData sources:

    Medline (1966–2004) and bibliographies of relevant studies and reviews.

    Embedded ImageStudy selection and assessment:

    randomised controlled trials (RCTs) that compared medical therapies with placebo or compared 2 separate agents in adults with constipation. Assessment of study quality was done using a 5 point score (5  =  highest quality) based on randomisation procedure, allocation concealment, blinding, and completeness of follow up.

    Embedded ImageOutcomes:

    stool frequency, stool consistency, straining, use of additional laxatives, ease of defecation, and side effects.

    MAIN RESULTS

    Laxatives evaluated were osmotic laxatives (eg, polyethylene …

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    Footnotes

    • A modified version of this abstract appears in ACP Journal Club.

    • For correspondence: Dr S S Rao, University of Iowa Carver College of Medicine, Iowa City, IA, USA. satish-raouiowa.edu

    • Source of funding: Novartis Pharmaceuticals.