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Evid Based Nurs 8:108 doi:10.1136/ebn.8.4.108
  • Treatment

Low dose aspirin lowered stroke risk but not risk of myocardial infarction or cardiovascular death in women

Aspirin v placebo for primary prevention of cardiovascular disease in women*

Outcomes at mean 10 years Aspirin Placebo RRR (95% CI) NNT (CI)
*Abbreviations defined in glossary; RRR, RRI, NNT, NNH, and CI calculated from data in article.
†Major cardiovascular event  =  non-fatal myocardial infarction, non-fatal stroke, or death from cardiovascular causes.
Major cardiovascular event† 2.4% 2.6% 9% (−3 to 20) Not significant
Stroke 1.1% 1.3% 17% (1 to 31) 445 (227 to 10377)
Death from cardiovascular causes 0.60% 0.63% 5% (−22 to 26) Not significant
Transient ischemic attack 0.93% 1.2% 22% (6 to 36) 385 (216 to 1687)
RRI (CI) NNH
Fatal or non-fatal myocardial infarction 0.99% 0.97% 2% (−16 to 25) Not significant
Gastrointestinal bleeding requiring transfusion 0.6% 0.5% 40% (7 to 83) 554 (305 to 2751)

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