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Evid Based Nurs 8:108 doi:10.1136/ebn.8.4.108
  • Treatment

Low dose aspirin lowered stroke risk but not risk of myocardial infarction or cardiovascular death in women


 
 Q Is low dose aspirin effective for primary prevention of cardiovascular disease in women?

METHODS

GraphicDesign:

randomised, placebo controlled trial (Women’s Health Study).

GraphicAllocation:

{concealed}.*

GraphicBlinding:

blinded {healthcare providers, participants, data collectors, and outcome assessors}.*

GraphicFollow up period:

mean 10 years.

GraphicSetting:

United States and Puerto Rico.

GraphicPatients:

39 876 women ⩾45 years of age (mean age 55 y) who had no history of coronary heart disease, cerebrovascular disease, cancer (except non-melanoma skin cancer), or other major chronic illness; had no history of side effects to study medications; were not using aspirin or non-steroidal anti-inflammatory medications; were not taking anticoagulants or corticosteroids; and were not taking vitamin A or E, or β carotene supplements more than once per week.

GraphicIntervention:

aspirin, 100 mg every other day (n = 19 934), or placebo (n = 19 942). …

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