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- aspirin
- cardiovascular diseases
- cerebrovascular accident
- cyclooxygenase inhibitors
- myocardial infarction
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Q Is low dose aspirin effective for primary prevention of cardiovascular disease in women?
METHODS
Design:
randomised, placebo controlled trial (Women’s Health Study).
Allocation:
{concealed}.*
Blinding:
blinded {healthcare providers, participants, data collectors, and outcome assessors}.*
Follow up period:
mean 10 years.
Setting:
United States and Puerto Rico.
Patients:
39 876 women ⩾45 years of age (mean age 55 y) who had no history of coronary heart disease, cerebrovascular disease, cancer (except non-melanoma skin cancer), or other major chronic illness; had no history of side effects to study medications; were not using aspirin or non-steroidal anti-inflammatory medications; were not taking anticoagulants or corticosteroids; …