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Aspirin, 1000 mg, reduced moderate to severe pain in acute migraine headache

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 Q Is a single dose of aspirin, 1000 mg, effective for treatment of acute migraine with moderate to severe pain intensity?


Embedded ImageDesign:

Randomised, placebo controlled trial.

Embedded ImageAllocation:

unclear concealment.

Embedded ImageBlinding:

blinded (patients).

Embedded ImageFollow up period:

several time points up to 24 hours.

Embedded ImageSetting:


Embedded ImagePatients:

485 patients who were 18–50 years of age (mean age 37 y, 79% women, 77% white); had experienced migraine headache, with or without aura, according to International Headache Society (IHS) criteria; had at least moderate pain; and had ⩾1 but ⩽6 migraines per month during the previous year. Exclusion criteria included vomiting ⩾20% of the time during an attack; initiation of preventive medication in the past 3 months or use of alkaloids to treat migraine; use of anticoagulant, gout, or arthritis medications; and previous non-responsiveness to medication for migraine.

Embedded ImageIntervention:

all patients were trained to identify a qualifying migraine attack (based on IHS criteria). Patients who had a qualifying …

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