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Evid Based Nurs 8:107 doi:10.1136/ebn.8.4.107
  • Treatment

Aspirin, 1000 mg, reduced moderate to severe pain in acute migraine headache

Aspirin, 1000 mg, v placebo for acute migraine with moderate to severe pain*

Outcomes at 2 hours Aspirin Placebo RBI (95% CI) NNT (CI)
*Abbreviations defined in glossary; RBI, RRI, NNT, NNH, and CI calculated from data in article.
†Response  =  change in pain intensity from moderate or severe at baseline to mild or none.
Response† 52% 34% 53% (21 to 94) 6 (4 to 12)
Pain free 20% 6% 233% (83 to 513) 8 (5 to 14)
Resolution of nausea 52% 43% 21% (−2 to 49) Not significant
Resolution of photophobia 30% 14% 114% (44 to 221) 7 (5 to 13)
Resolution of phonophobia 34% 17% 100% (40 to 188) 6 (4 to 12)
RRI (95% CI) NNH
Any adverse event over 24 hours 8.8% 4.9% 79% (−14 to 273) Not significant

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