Aspirin, 1000 mg, reduced moderate to severe pain in acute migraine headache
Q Is a single dose of aspirin, 1000 mg, effective for treatment of acute migraine with moderate to severe pain intensity?
METHODS
Design:
Randomised, placebo controlled trial.
Allocation:
unclear concealment.
Blinding:
blinded (patients).
Follow up period:
several time points up to 24 hours.
Setting:
USA.
Patients:
485 patients who were 18–50 years of age (mean age 37 y, 79% women, 77% white); had experienced migraine headache, with or without aura, according to International Headache Society (IHS) criteria; had at least moderate pain; and had ⩾1 but ⩽6 migraines per month during the previous year. Exclusion criteria included vomiting ⩾20% of the time during an attack; initiation of preventive medication in the past 3 months or use of alkaloids to treat migraine; use of anticoagulant, gout, or arthritis medications; and previous non-responsiveness to medication for migraine.
Intervention:
all patients were trained to identify a qualifying migraine attack (based on IHS criteria). Patients who had a qualifying …
