Evid Based Nurs 8:86 doi:10.1136/ebn.8.3.86
  • Treatment

Review: statins reduce non-fatal and fatal strokes in patients with and without coronary heart disease

Statins v control interventions for prevention of non-fatal and fatal stroke (follow up 0.5 to 6.1 y)*

Weighted event rates
Patients Number of trials (n) Statins Control RRR (95% CI) NNT (CI)
*CHD  =  coronary heart disease; other abbreviations defined in glossary. RRR, NNT, and CI calculated from data in article using a random effects model. Patients in 6 of the 29 statin trials could not be classified as having or not having CHD because 10–90% of patients had CHD.
With and without CHD 29 (93 399) 3.2% 3.6% 18% (10 to 24) 220 (140 to 504)
With CHD 17 (25 718) 2.6% 3.2% 25% (13 to 35) 190 (112 to 634)
Without CHD 6 (19 567) 1.4% 1.9% 23% (5 to 38) 159 (129 to 1667)

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