Evid Based Nurs 8:83 doi:10.1136/ebn.8.3.83
  • Treatment

Review: plant based oestrogens do not relieve hot flushes or other menopausal symptoms

Phyto-oestrogens v placebo or non-phyto-oestrogen control for hot flushes and other menopausal symptoms*

Number of RCTs showing improvement/total number of RCTs measuring outcome
Phyto-oestrogen Number of RCTs (n) Hot flush frequency Menopausal symptoms
*RCTs  =  randomised controlled trials. Mean study duration was 17 weeks.
†Improvement in some subscales (vaginal dryness [1 RCT], hot flush severity [2 RCTs], and oestrogenic symptoms [1 RCT]).
‡Improvement in Kupperman index score (1 RCT), hot flushes and night sweats (1 RCT), 12 of 15 domains of a symptom questionnaire (1 RCT), and hot flush rate and symptom scores (no statistical comparison) (1 RCT).
Soy foods, beverages, or powders 11 (1094) 1/8 2/8†
Soy extracts 9 (854) 2/6 4/5‡
Red clover extracts 5 (400) 2/5 0/5

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