High dose (⩾400 IU/d), low dose (<400 IU/d), and all doses of vitamin E supplementation v placebo or no vitamin E for all cause mortality*
| Number of trials (n) | Vitamin E dose | RRI (95% CI) | Risk difference per 10 000 persons (CI) | NNH (CI) |
|---|---|---|---|---|
| *Abbreviations defined in glossary; RRI, RRR, NNH NNT, and CI calculated from data in article. Follow up ranged from 1.4 to 8.2 years. A dose-response regression model was used. | ||||
| †Favours placebo or no vitamin E. | ||||
| 19 (135 967) | High and low | 1% (−2 to 4) | 10 (−18 to 38) | Not significant |
| 11 (40 950) | High | 4% (1 to 7) | 39 (3 to 74)† | 257 (136 to 3334) |
| RRR (CI) | NNT | |||
| 8 (95 017) | Low | 2% (−1 to 4) | −16 (−41 to 10) | Not significant |
