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Evid Based Nurs 8:82 doi:10.1136/ebn.8.3.82
  • Treatment

Review: high dose vitamin E supplementation is associated with increased all cause mortality

High dose (⩾400 IU/d), low dose (<400 IU/d), and all doses of vitamin E supplementation v placebo or no vitamin E for all cause mortality*

Number of trials (n) Vitamin E dose RRI (95% CI) Risk difference per 10 000 persons (CI) NNH (CI)
*Abbreviations defined in glossary; RRI, RRR, NNH NNT, and CI calculated from data in article. Follow up ranged from 1.4 to 8.2 years. A dose-response regression model was used.
†Favours placebo or no vitamin E.
19 (135 967) High and low 1% (−2 to 4) 10 (−18 to 38) Not significant
11 (40 950) High 4% (1 to 7) 39 (3 to 74)† 257 (136 to 3334)
RRR (CI) NNT
8 (95 017) Low 2% (−1 to 4) −16 (−41 to 10) Not significant

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