Review: high dose vitamin E supplementation is associated with increased all cause mortality
Q Does vitamin E supplementation increase all cause mortality? Does a dose-response relation exist between vitamin E and all cause mortality?
Medline (1966 to August 2004), Cochrane Central Register of Controlled Trials, bibliographies of relevant studies and reviews, and personal files of the investigators.
Study selection and assessment:
randomised controlled trials (RCTs) that compared vitamin E supplementation (alone or combined with other vitamins or minerals) with a control or placebo group in men or non-pregnant women, study duration and follow up were >1 year, and ⩾10 deaths occurred.
all cause mortality.
19 RCTs (n = 135 967, mean age range 47–84 y) met the selection criteria. 9 RCTs evaluated vitamin E alone, and 10 combined vitamin E with other vitamins or minerals. 16 RCTs were placebo …