Review: high dose vitamin E supplementation is associated with increased all cause mortality
Q Does vitamin E supplementation increase all cause mortality? Does a dose-response relation exist between vitamin E and all cause mortality?
METHODS
Data sources:
Medline (1966 to August 2004), Cochrane Central Register of Controlled Trials, bibliographies of relevant studies and reviews, and personal files of the investigators.
Study selection and assessment:
randomised controlled trials (RCTs) that compared vitamin E supplementation (alone or combined with other vitamins or minerals) with a control or placebo group in men or non-pregnant women, study duration and follow up were >1 year, and ⩾10 deaths occurred.
Outcomes:
all cause mortality.
MAIN RESULTS
19 RCTs (n = 135 967, mean age range 47–84 y) met the selection criteria. 9 RCTs evaluated vitamin E alone, and 10 combined vitamin E with other vitamins or minerals. 16 RCTs were placebo …
