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Maintenance and symptom relief with budesonide plus formoterol reduced severe asthma exacerbations

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Q In patients with asthma, is budesonide (BUD) plus formoterol (FORM) (BUDFORM) for both maintenance and symptom relief more effective than fixed dosing using BUDFORM or a 4 fold higher dose of BUD, both with a short acting β2 agonist (SABA), for reducing the rate of severe asthma exacerbations?

METHODS

Embedded ImageDesign:

randomised controlled trial.

Embedded ImageAllocation:

concealed.

Embedded ImageBlinding:

blinded (patients and healthcare providers).

Embedded ImageFollow up period:

1 year

Embedded ImageSetting:

246 centres in 22 countries.

Embedded ImagePatients:

2760 outpatients (mean age 36 y, 55% women/girls; 12% children 4–11 y) with asthma who were using inhaled corticosteroids (ICSs).

Embedded ImageIntervention:

BUDFORM (BUD, 80 μg plus FORM, 4.5 μg) both for …

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