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Evid Based Nurs 8:53 doi:10.1136/ebn.8.2.53
  • Treatment

Review: a single dose of oral naproxen or naproxen sodium reduced acute postoperative pain in adults

Naproxen sodium (NapS) or naproxen (Nap) v placebo for acute postoperative pain in adults*

Outcome at 4–6 hours Number of trials (n) Drug and dosage Weighted event rates (NapS/Nap v placebo) RBI (95% CI) NNT (CI)
*NS  =  not significant; other abbreviations defined in glossary. Weighted event rates, RBI, RRR, RRI, and CI calculated from data in article (based on a fixed effects model).
⩾50% pain relief 6 (n = 500) NapS, 550 mg 50% v 12% 318% (193 to 497) 3 (3 to 4)
3 (n = 334) NapS/Nap, 440/400 mg 50% v 11% 380% (175 to 738) 3 (3 to 4)
2 (n = 202) NapS/Nap, 220/200 mg 44% v 16% 187% (60 to 415) 4 (3 to 6)
RRR (CI)
⩾1 adverse event 5 (n = 392) NapS, 550 mg 24% v 27% 11% (−25 to 37) NS
RRI (CI) NNH (CI)
2 (n = 257) NapS/Nap, 440/400 mg 22% v 17% 32% (−22 to 124) NS
1 (n = 122) NapS/Nap, 220/200 mg 26% v 12% 121% (−10 to 443) NS

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