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Evid Based Nurs 8:49 doi:10.1136/ebn.8.2.49
  • Treatment

Fluconazole reduced the rate of recurrence of vulvovaginal candidiasis


 
 Q What is the efficacy of fluconazole for recurrent vulvovaginal candidiasis (VC)?

METHODS

GraphicDesign:

randomised placebo controlled trial.

GraphicAllocation:

unclear.

GraphicBlinding:

blinded (patients and healthcare providers).

GraphicFollow up period:

12 months.

GraphicSetting:

multiple centres in the US.

GraphicPatients:

387 women ⩾18 years of age (mean age 34 y, 67% white) who had active, acute candida vaginitis (severity score ⩾3), a positive result on microscopic examination of vaginal secretions, ⩾4 episodes of candida vaginitis in the previous 12 months, and were clinically cured (severity score <3) at 14 days after receiving 3 sequential doses of fluconazole, 150 mg, at 72 hour intervals. Exclusion criteria: lack of confirmation of microscopic findings by culture, pregnancy, mixed infections or known seropositivity for HIV, or use of antifungal agents in the previous 4 weeks.

GraphicIntervention:

a single oral dose of fluconazole, 150 mg (n = 170),* or an oral placebo tablet taken weekly for 6 months (n = 173).*

GraphicOutcomes:

clinical recurrence of …

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