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Evid Based Nurs 8:47 doi:10.1136/ebn.8.2.47
  • Treatment

Review: vaccination reduces the incidence of serologically confirmed influenza in healthy adults

Influenza vaccines (inactivated parenteral vaccine [IP], live aerosol vaccine [LA], or inactivated aerosol vaccine [IA]) v placebo for preventing influenza in healthy persons 14–60 years of age at a mean follow up of 87 days*

Outcome Number of trials (n) Comparison Weighted event rates RRR (95% CI)† NNT (CI)
*CDI  =  clinically defined influenza; SCI  =  serologically confirmed influenza. Other abbreviations defined in glossary; weighted event rates, NNT, and CI calculated from data in article using a random effects model.
†RRR is referred to as vaccine efficacy in the original Cochrane review.
CDI unspecified 8 (6566) IP v placebo 17% v 21% 31% (5 to 51) 25 (13 to ∞)
2 (438) IA v placebo 7% v 20% 65% (32 to 82) 8 (4 to 50)
CDI specified 10 (4271) IP v placebo 36% v 44% 22% (9 to 33) 12 (7 to 34)
2 (4591) LA v placebo 20% v 23% 15% (5 to 24) 34 (17 to 100)
2 (1069) IA v placebo 20% v 28% 27% (0 to 47) 17 (7 to ∞)
SCI 9 (2411) IP v placebo 2% v 8% 67% (51 to 78) 17 (13 to 34)
2 (427) LA v placebo 0.5% v 8.5% 79% (44 to 92) 13 (6 to ∞)

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