Review: vaccination reduces the incidence of serologically confirmed influenza in healthy adults
Q Is vaccination effective for reducing the incidence of influenza in healthy people 14–60 years of age?
Cochrane Central Register of Controlled Trials (Cochrane Library, Issue 1, 2004), MEDLINE (1966–2003), EMBASE/Excerpta Medica (1990–2003), bibliographies of relevant articles, and manufacturers and researchers.
Study selection and assessment:
controlled trials (published in any language) that evaluated the effectiveness of influenza vaccines for protection from exposure to naturally occurring influenza in healthy people 14–60 years of age.
incidence of clinically defined influenza (CDI) (unspecified or specified on the basis of specific symptoms or signs) and serologically confirmed influenza (SCI).
47 trials (25 randomised controlled trials [RCTs], n = 59 566) met the selection criteria. (1) Influenza vaccine (inactivated parenteral vaccine [IP], live aerosol vaccine [LA], or inactivated aerosol vaccine [IA]) v placebo. Rates of CDI and SCI were lower in the IP …