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Evid Based Nurs 8:47 doi:10.1136/ebn.8.2.47
  • Treatment

Review: vaccination reduces the incidence of serologically confirmed influenza in healthy adults


 
 Q Is vaccination effective for reducing the incidence of influenza in healthy people 14–60 years of age?

METHODS

GraphicData sources:

Cochrane Central Register of Controlled Trials (Cochrane Library, Issue 1, 2004), MEDLINE (1966–2003), EMBASE/Excerpta Medica (1990–2003), bibliographies of relevant articles, and manufacturers and researchers.

GraphicStudy selection and assessment:

controlled trials (published in any language) that evaluated the effectiveness of influenza vaccines for protection from exposure to naturally occurring influenza in healthy people 14–60 years of age.

GraphicOutcomes:

incidence of clinically defined influenza (CDI) (unspecified or specified on the basis of specific symptoms or signs) and serologically confirmed influenza (SCI).

MAIN RESULTS

47 trials (25 randomised controlled trials [RCTs], n = 59 566) met the selection criteria. (1) Influenza vaccine (inactivated parenteral vaccine [IP], live aerosol vaccine [LA], or inactivated aerosol vaccine [IA]) v placebo. Rates of CDI and SCI were lower in the IP …

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