Dexamethasone reduced the incidence of children with mild croup who returned for medical care
Q Does dexamethasone reduce the incidence of children with mild croup who return for medical care more than placebo?
randomised placebo controlled trial.
unclear allocation concealment.
blinded (patients and data analysts).
Follow up period:
7 days after treatment.
4 paediatric emergency departments (EDs) in Canada.
720 children (mean age 35 mo, 61% boys) with mild croup (onset of a seal like, barking cough in the previous 72 h and ⩽2 out of 17 points on a validated croup scoring system). Exclusion criteria included other respiratory disorders, severe systemic disease, immune dysfunction, corticosteroids within the previous 2 weeks, epinephrine for respiratory distress, and previous ED visit for this croup episode.
single oral dose of dexamethasone suspension (12.5 ml DM phosphate injection plus 50 ml of cherry flavoured syrup, 0.6 mg/kg of body weight (maximum 20 mg) (n = 359) or placebo (10 ml of distilled water plus …