Evid Based Nurs 8:9 doi:10.1136/ebn.8.1.9
  • Treatment

Elective surfactant increased median duration of mechanical ventilation in preterm infants with mild to moderate respiratory distress syndrome

 Q What is the efficacy of elective brief intubation for early single dose surfactant administration compared with administration as clinically indicated for preterm infants with mild to moderate respiratory distress syndrome (RDS) not requiring mechanical ventilation?



randomised controlled trial.




unclear if blinded.

GraphicFollow up period:

up to discharge from hospital.


5 centres in Texas, USA.


136 infants with birth weights ⩾1250 g, gestational age ⩽36 completed weeks, postnatal age 4–24 hours, FIO2⩾0.40 with or without nasal continuous positive airway pressure (CPAP), RDS (based on chest radiograph and clinical presentation), no requirement for mechanical ventilation, no previous treatment with surfactant, no known cardiac or respiratory related congenital anomalies, and no anomalies incompatible with survival.


65 infants received elective surfactant treatment, which comprised intubation, administration of a single dose of surfactant, 4 ml/kg, (Suranta, Ross Laboratories, …

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