|Question||Study groups||Outcomes at 1–7 days (5 trials)||Weighted EER||Weighted CER||RBR (95% CI)||NNH|
|Conclusion: in patients with acute upper respiratory infection, antibiotics are no more beneficial in terms of general improvement than placebo and are associated with a non-significant increase in adverse effects.|
|*EER = experimental event rate, CER = control event rate, RBR = relative benefit reduction, RRI = relative risk increase, NS = not statistically significant.; RBR, RRI, NNH, and CI calculated from data in article.|
|In patients with acute respiratory tract infections, what is the efficacy and safety of antibiotics (compared with placebo) in curing infection and improving nasopharyngeal symptoms?||Experimental: antibiotics (tetracycline, penicillin, ampicillin, amoxicillin, erythromycin, and cotrimoxizole) Control: placebo||General improvement||51.2%||52.5%||2% (−5 to 10)||NS|
|Adverse effects||9.7%||3.6%||82% (−25 to 340)||NS|
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